Orbeseal is indicated for the prevention of new intramammary infections throughout the dry period in cattle. In cows likely to be free of subclinical mastitis, OrbeSeal can be used on its own in dry cow management and mastitis control. In cows that may have subclinical mastitis, OrbeSeal may be used following administration of a suitable dry cow antibiotic treatment to the infected quarter. Selection of cows for treatment with OrbeSeal should be based on veterinary clinical judgement. Selection criteria may be based on the mastitis and cell count history of individual cows, or recognized test for the detection of subclinical mastitis or bacteriological sampling.