Mepivacaine hydrochloride


PDF Product Sheet MEPIDOR


Each ml contains :

Mepivacaine hydrochloride 20mg
(equivalent to 17,4mg Mepivacaine)

Mepivacaine hydrochloride is a potent local anaesthetic, with a rapid onset of action. Since is does not cause vasodilation it does not require adrenaline to prolong its effect. The mechanism of action of mepivacaine is to prevent the generation and conduction of the nerve impulse. Conduction is blocked by decreasing or preventing the large transient increase in the permeability of excitable membranes to Na+  that is produced by a slight depolarisation. This action is due to a direct effect with voltage sensitive Nachannels. Mepivacaine exists in both charged and uncharged forms at physiological pH while the intracellular environment favours formation of the active, charged molecule. The onset of action of mepivacaine is, therefore, rapid (2-4 minutes) with an intermediate duration of actions (about 1 hour)


Mepivacaine is indicated for infiltration, nerve block, intra-articular and epidural anaesthesia in noon-food producing horses.