Ostenil Plus

Sodium hyaluronate from fermentation



Each ml contains:

Sodium hyaluronate from fermentation and sodium chloride 20 mg

Disodium phosphate, Sodium dihydrogenphosphate, Mannitol, Water for injections


Medical device.

Synovial fluid, which is viscoelastic due to the presence of hyaluronic acid, is found in all synovial joints, particularly the large weight bearing joints, where it ensures normal, painless movement due to its lubricating and shock-absorbing properties. It is also responsible for the nutrition of the cartilage.


Pain and restricted mobility in degenerative and traumatic changes of the knee joint and other synovial joints. In degenerative joint disorders such as osteoarthritis, the viscoelasticity of the synovial fluid is markedly reduced thereby decreasing its lubricating and shock-absorbing functions. This increases mechanical loading of the joint and cartilage destruction which ultimately results in pain and restricted mobility of the affected joint. Supplementing this synovial fluid with intra-articular injections of highly purified hyaluronic acid can ameliorate the viscoelastic properties synovial fluid. This improves its lubricating and shock-absorbing functions and reduces mechanical overload  of the joint. As a rule this results in a decrease in pain and an improvement in joint mobility which may last for several months after a treatment cycle.